天然荜茇酰胺衍生物合成及生物活性研究进展

龙雪莎, 王钦, 汪从雨, 王贞超, 欧阳贵平

中国药学杂志 ›› 2022, Vol. 57 ›› Issue (22) : 1865-1872.

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中国药学杂志
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中国药学杂志 ›› 2022, Vol. 57 ›› Issue (22) : 1865-1872. DOI: 10.11669/cpj.2022.22.001
综述

天然荜茇酰胺衍生物合成及生物活性研究进展

  • 龙雪莎1, 王钦1, 汪从雨1, 王贞超1,2,3*, 欧阳贵平1,2,3*
作者信息 +

An Overview of Synthesis and Bioactivities of Derivatives Based on the Structure of Natural Product Piperlongumine

  • LONG Xue-sha1, WANG Qin1, WANG Cong-yu1, WANG Zhen-chao1,2,3*, OUYANG Gui-ping1,2,3*
Author information +
文章历史 +

摘要

荜茇酰胺是源自胡椒科植物荜茇中的一种生物碱,学者们通过研究荜茇酰胺及其衍生物,发现其具有广泛的生理活性,包括:抗炎、神经保护、抗虫、抗肝纤维化、抗血管钙化及抗癌等。荜茇酰胺结构主要存在3个反应位点,笔者从荜茇酰胺出发,以其不同反应位点为线索,阐述荜茇酰胺及其衍生物的合成及其生物活性,同时浅谈其作用机制,为荜茇酰胺的新药研发提供科学依据。

Abstract

Piperlongumine is an alkaloid derived from Piper longum L. Through studies on piperlongumine and its derivatives, scientists have found that piperlongumine has a wide range of physiological activities, including anti-inflammatory, neuroprotective, anti-insect, anti-liver fibrosis, anti-vascular calcification, anti-tumor, etc. There are mainly three reaction sites in the structure of piperlongumine. Starting from piperlongumine, this paper elaborates the synthesis of piperlonguine and its derivatives, the biological activities of these compounds, and the mechanism of action according to the clues of different reaction sites. It provides scientific basis for the research and development of new drugs based on piperlongumine.

关键词

荜茇酰胺 / 衍生物 / 生物活性 / 合成 / 抗癌

Key words

piperlongumine / derivatives / biological activity / synthesis / anti-tumor

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导出引用
龙雪莎, 王钦, 汪从雨, 王贞超, 欧阳贵平. 天然荜茇酰胺衍生物合成及生物活性研究进展[J]. 中国药学杂志, 2022, 57(22): 1865-1872 https://doi.org/10.11669/cpj.2022.22.001
LONG Xue-sha, WANG Qin, WANG Cong-yu, WANG Zhen-chao, OUYANG Gui-ping. An Overview of Synthesis and Bioactivities of Derivatives Based on the Structure of Natural Product Piperlongumine[J]. Chinese Pharmaceutical Journal, 2022, 57(22): 1865-1872 https://doi.org/10.11669/cpj.2022.22.001
中图分类号： R914   

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基金

国家自然科学基金项目资助(22007022);贵州省科技计划项目资助(黔科合基础-ZK重点 034)
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